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This page is for archiving purposes only; several methodological guidelines created under EUnetHTA activities have been reworked and adapted for the joint work under the HTA regulation.

Methodological Guidelines

Title Version Last update Link
Comparators & Comparisons - Criteria for the choice of the most appropriate comparator(s) 2.0 2015 PDF Version
Comparators & Comparisons - Direct and indirect comparisons 2.0 2015 PDF Version
Endpoints used for Relative Effectiveness Assessment - Clinical Endpoints 2.0 2015 PDF Version
Endpoints used for Relative Effectiveness Assessment - Composite endpoints 2.0 2015 PDF Version
Endpoints used for Relative Effectiveness Assessment - Health related quality of life and utility measures 2.0 2015 PDF Version
Endpoints used in Relative Effectiveness Assessment - Safety 2.0 2015 PDF Version
Endpoints used in Relative Effectiveness Assessment - Surrogate Endpoints 2.0 2015 PDF Version
Internal validity of non-randomised studies (NRS) on interventions 1.0  2015 PDF Version
Internal validity of randomised controlled trials 2.0 2015 PDF Version
Levels of Evidence – Applicability of evidence for the context of a relative effectiveness assessment 2.0 2015 PDF Version
Meta-analysis of diagnostic test accuracy studies 1.0  2014 PDF Version
Methods for health economic evaluations – A guideline based on current practices in Europe 1.0  2015 PDF Version
Personalised Medicine and Co-Dependent Technologies 1.0  2015 PDF Version
Practical considerations when critically assessing economic evaluations 1.0  2020 PDF Version
Process of information retrieval for systematic reviews and health technology assessments on clinical effectiveness 2.0 2019 PDF Version
Therapeutic medical devices 1.0  2015 PDF Version